June 22, 2009 — The selective serotonin-reuptake inhibitor (SSRI) paroxetine (Paxil, GlaxoSmithKline) may affect male fertility through its effects on sperm DNA, according to a small study by Weill Cornell Medical Center researchers. In the study of 35 healthy volunteers without psychiatric disorders, the antidepressant induced abnormal sperm DNA fragmentation in more than 40% of participants.
"Sperm DNA fragmentation is thought to be a very sensitive measure of sperm abnormality, independent of sperm counts or standard sperm tests, and predicts natural fertility as well as fertility with the most advanced forms of assisted reproduction, such as in vitro fertilization," said senior author Peter Schlegel, MD, chair of the department of urology and professor of reproductive medicine at Weill Cornell Medical Center, in New York City. "What the study tells us is that paroxetine could have an effect on fertility that will not show up in standard sperm tests — and cause an increase in genetic damage to sperm," he said.
Monday, November 09, 2009
SSRIs may be bad for sperm
Eeek, besides the disturbing fact that so many of those crazy shooters (now, Columbine, and back) have been on SSRIs, which of course affect the biochemistry of your brain, apparently it looks like SSRIs may cause MAJOR DNA damage in sperm. The study used Paxil (interestingly, I have seen articles pushing Paxil as it's cheaper than other SSRIs) but researchers hypothesize it's ALL SSRIs. From Medscape.com: